Pigment Epithelium-derived Factor (PEDF) Prevents Retinal Cell Death via PEDF Receptor (PEDF-R)
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Pigment Epithelium-derived Factor (PEDF) Prevents Retinal Cell Death via Pigment Epithelium- derived Factor-R (PEDF-R): Identification of a Functional Ligand Binding Site*
Background: PEDF has neurotrophic activity and interacts with PEDF-R, a membrane-linked lipase. Results: A PEDF-binding region of PEDF-R is required for PEDF-R enzymatic stimulation and peptides derived from this region block PEDF/PEDF-R-mediated retinal survival activities. Conclusions: A ligand binding domain is identified in PEDF-R, a critical receptor for PEDF’s survival activity. Significa...
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Pigment epithelial-derived factor (PEDF) is known as a widely expressed multifunctional secreted glycoprotein whose biological actions are cell-type dependent. Recent studies demonstrated that PEDF displays cytoprotective activity in several cell types. However, it remains unknown whether PEDF is involved in glucocorticoid-induced osteoblast death. The aim of this study was to examine the role ...
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BACKGROUND Pigment epithelium-derived factor (PEDF), which belongs to the noninhibitory serpin family, has shown the ability to stimulate several physiological processes, such as antiangiogenesis, anti-inflammation, and antioxidation. In the present study, the effects of PEDF on contractility and calcium handling of rat ventricular myocytes were investigated. METHODS AND RESULTS Adult Sprague...
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RECEPTOR FOR PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF)* Luigi Notari, Victoriano Baladron, J. Daniel Aroca-Aguilar, Natalia Balko, Raul Heredia, Christina Meyer, Patricia M. Notario, Senthil Saravanamuthu, Maria-Luisa Nueda, Francisco Sanchez-Sanchez, Julio Escribano, Jorge Laborda, S. Patricia Becerra From the National Eye Institute, National Institutes of Health, and Food and Drug Administrati...
متن کاملPigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity.
Neuroblastoma is notable for its cellular heterogeneity and unpredictable outcome. Tumors are a variable mixture of primitive malignant neuroblasts, more differentiated ganglionic cells, Schwann and endothelial cells. Although often fatal, neuroblastomas can spontaneously regress, possibly due to favorable autocrine and paracrine interactions among these cells. Here, pigment epithelium-derived ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2013
ISSN: 0021-9258
DOI: 10.1074/jbc.m113.487884